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KMID : 1134820200490070668
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Journal of the Korean Society of Food Science and Nutrition
2020 Volume.49 No. 7 p.668 ~ p.676
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Anti-Cancer Effect of 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucose in B16-F0, Mouse Melanoma
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Lee Seong-Uk
Kim Yoon-Hee
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Abstract
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1,2,3,4,6-Penta-O-galloyl-β-D-glucose (PGG) is a hydrolyzed tannin isolated from plants such as Galla Rhois. This study evaluated the effects of PGG in B16-F0, mouse melanoma, and its molecular mechanism. PGG inhibited cell proliferation and induced cytotoxicity. In addition, PGG suppressed the clonogenic activity and inhibited the cell cycle by inhibiting the G1 and S phase. PGG impeded the protein expression of cyclin-dependent kinase 2 and cyclin E, which are checkpoint system-related proteins for the cell cycle. PGG also induced early and late apoptosis by increasing the protein expression of the intrinsic (cytochrome C and cleaved caspase-9) pathway and the extrinsic pathway (Fas- associated protein with death domain, cleaved caspase-8, cleaved caspase-3, and cleaved poly adenosine diphosphate-ribose polymerase). These data suggest that PGG might be a potential therapeutic compound for melanoma.
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KEYWORD
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PGG, tannin, melanoma, apoptosis, anti-cancer
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